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Root-Derived Secretions for Beneficial Biotic Interactions
In the agriculture industry,
plant disease can generally reduce annual yields by 10%. Thus, disease … moreIn the agriculture industry,
plant disease can generally reduce annual yields by 10%. Thus, disease
resistance is crucial for the production of food as well for the agricultural
use of fuel, water, and land. This invention involves using a specific plant
root secretion as a compound to recruit beneficial microbes, which in turn
induces resistance in plants against various foliar pathogens.
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Primary:
University of Delaware
Date posted:
May 3, 2012
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Generation of Asporogenous Solventogenic Clostridia for Production of Butanol by Inactivating The Gene That Codes for SpoIIE (Jointly Owned With Northwestern University)
In wild-type (WT) cultures of
solventogenic Clostridium strains,
desired solvent formation is coupled with sporulation … moreIn wild-type (WT) cultures of
solventogenic Clostridium strains,
desired solvent formation is coupled with sporulation. In bioprocessing,
sporulation is often undesirable due to its inhibition of cellular growth,
dilution of the population of solvent forming cells, and high energy cost. This
invention provides a method for decoupling solvent formation from sporulation
by inactivating the protein expression of spoIIE,
leading to the creation of various non-sporulating Clostridium strains with enhanced production capabilities for
chemical products such butanol, butyric acid, acetoin, butanediol, and propanol.
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Primary:
University of Delaware
Date posted:
May 3, 2012
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Co-Existing Genomic Libraries for Identifying and Developing Microbial Strains Exhibiting Complex Phenotypic Behavior
The core
principle of the invention is that of co-existing and interacting multiple
genomic or … more
The core
principle of the invention is that of co-existing and interacting multiple
genomic or subgenomic libraries in any desirable cell. For the case of two (2)
co-existing libraries, each cell will contain one genomic insert from each of
the two libraries, and the whole population of the cells will be large enough
so that all possible binary combinations of all inserts of the two libraries
are represented in the population and can be screened for a desirable trait
that is the result of the interaction of the inserts from the two libraries. In
principle, this can be generalized to three (3) co-existing libraries, but
practically this will be difficult to accomplish so that all possible and
unbiased trinary combinations of inserts can be represented in a cell
population. There are strategies that can overcome this difficulty if some
additional assumptions are made. The complementation of the MG655 DlysADdapA and the
MG1655 DdapDDdapE double
knockouts are working prototypes of the invention.
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Primary:
University of Delaware
Date posted:
May 1, 2012
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Fluorescent Sensors of Tyrosine Phosphorylation
The invention is a novel means for the fluorescent detection
of tyrosine activity. A phosphotyrosine is used … more
The invention is a novel means for the fluorescent detection
of tyrosine activity. A phosphotyrosine is used to mimic a glutamic acid
residue, Unlike previous methods, this approach combines a genetic encodability
with the exhibition of large fluorescence changes upon phosphorylation.
Moreover, this approach is applicable to different kinases and phosphotases
through modification of the recognition sequence.
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Primary:
University of Delaware
Date posted:
May 1, 2012
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Plant Microbe Based Method to Enchance Biomass, Yield Potential, and Drought Tolerance in Plants
This invention relates
to a method that exploits plant microbe partnership to induce biomass and
drought … moreThis invention relates
to a method that exploits plant microbe partnership to induce biomass and
drought intolerance in plant species.
Unlike transgenic approaches, this method is immediately
applicable to any plant, without the time required for gene identification,
generation and characterization of transgenic lines. Compared to the use of
traditional agronomic practices (applications of chemical fertilizers and
water), this new method is less resource and labor intensive for the grower and
is more environmentally-friendly. In addition, application of chemical
fertilizers is known to enhance crop disease susceptibility by the induction of
rapid weak growth, whereas plants grown with this method do not demonstrate
enhanced disease susceptibility. Finally, this method is compatible with
organic farming practices.
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Primary:
University of Delaware
Date posted:
May 1, 2012
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Safety Electrical Plug and Receptacle
This
invention relates to an innovative design of a safety electrical plug and
receptacle that achieves … moreThis
invention relates to an innovative design of a safety electrical plug and
receptacle that achieves two important features: 1) In a conventional AC
environment, the receptacle is not energized until the plug is fully engaged,
thus providing power only to the
properly inserted male plug. 2) In a DC environment, the invention terminates
the current before the plug is removed, thus preventing an arc from forming.
The arc is a potential fire hazard and causes some of the metal at the tips of
the prongs and the receptacle to vaporize, thus reducing the lifetime of the
receptacle and causing pitting.
Most efforts to devise a safer electrical
receptacle have concentrated on quickly interrupting a live circuit when a
trigger event occurs or on some sort of mechanical arrangement to prevent non-plugs from properly engaging the
female contacts, which are often unreliable. This invention involves an
optoelectronic circuit of easy implementation.
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Primary:
University of Delaware
Date posted:
May 1, 2012
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Method for Detection and Quantification of Cryptic Replication in HIV Using 2-LTR Based Measurements
This invention is a method for
the detection and quantification of cryptic replication in HIV. The … moreThis invention is a method for
the detection and quantification of cryptic replication in HIV. The durability
and effectiveness of current treatment options such as Highly Active
Antiretroviral Therapy (HAART) or reservoir flushing methods may be influenced
by the rates of ongoing viral replication that are below the standard limit of
detection. This diagnostic tool addresses the current problem with detecting
the continuing replication of HIV in anatomically remote compartments that
cannot be measured with other techniques, such as plasma HIV RNA PCR
measurements.
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Primary:
University of Delaware
Date posted:
Apr 27, 2012
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Engineering Acid Tolerance in Microbes by Overexpression of Single Genes or Co-Overexpression of Two or More Genes and Small RNAs
The invention provides a method
to impart tolerance to low pH or acid to various industrially … moreThe invention provides a method
to impart tolerance to low pH or acid to various industrially important
microbes. The engineering of process organisms that are sturdy and tolerant is
an attractive goal in the bioprocessing industry. Acid tolerance during active
growth is one such desirable trait, paramount in efforts to make biorefining
and biofuels economically competitive. By screening co-existing genomic
libraries to identify determinants that impart tolerance to low pH or acid,
several genes were identified that can provide drastically higher acid
tolerance upon overexpression in a cell. These genes are both novel and unique
to this application.
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Primary:
University of Delaware
Date posted:
Apr 27, 2012
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ASK1 Inhibition for Anti-Thrombosis
The invention provides details
on a novel anti-thrombotic drug. Research has indicated the presence of a
protein … moreThe invention provides details
on a novel anti-thrombotic drug. Research has indicated the presence of a
protein called ASK1 expressed in platelets, the key players in the pathology of
thrombosis. Research has also indicated that this protein may be the key
regulator in platelet function, and thus thrombosis. Inactivation of this
protein has been shown to greatly protect from experimental thrombosis without
the side effect of bleeding.
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Primary:
University of Delaware
Date posted:
Apr 27, 2012
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Expression of Wood-Ljungdahl Pathway Genes in the Organism Class of Clostridia and Other Anaerobes (Jointly Owned with Northwestern University)
The invention provides details
on a novel anti-thrombotic drug via a specific protein inactivation. Research
has indicated … moreThe invention provides details
on a novel anti-thrombotic drug via a specific protein inactivation. Research
has indicated the presence of this protein expressed in platelets, the key
players in the pathology of thrombosis. Research has also indicated that this
protein may be the key regulator in platelet function, and thus thrombosis.
Inactivation of this protein has been shown to greatly protect from
experimental thrombosis without the side effect of bleeding.
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Primary:
University of Delaware
Date posted:
Apr 27, 2012
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